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Daunorubicin efflux against a concentration gradient in non-P-glycoprotein multidrug-resistant lung-cancer cells


Book ID
123164911
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
147 KB
Volume
12
Category
Article
ISSN
0169-5002

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Daunorubicin efflux against a concentrat
✍ H. Sipko MΓΌlder; Jan Lankelma; Henk Dekker; Henk J. Broxterman; Herbert M. Pined πŸ“‚ Article πŸ“… 1994 πŸ› John Wiley and Sons 🌐 French βš– 948 KB

Multidrug-resistant, human non-small-cell lung carcinoma SW-I573/ZR120 (2RI2O) cells, not containing the drug efflux pump P-&coprotein (Pgp), have reduced initial daunorubicin (DN) accumulation rates and decreased cellular steady-state drug concentrations. Previously we found indications of the pres