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Database and software for the analysis of mutations at the lacZ locus in transgenic rodents

โœ Scribed by Neal F. Cariello; George R. Douglas

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
840 KB
Volume
28
Category
Article
ISSN
0893-6692

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โœฆ Synopsis

The use of transgenic rodents is becoming increasstrand bias, 3) determine the frequency of transiingly widespread in genetic toxicology. In an effort tions and transversions, 4) display the number and to centralize and standardize the information r e kind of mutations observed at each base in the codgarding mutations in rodents bearing the IacZ ing region, 5) perform nearest-neighbor analysis, transgene, we have created a computerized data-and 6) display mutable amino acids in the lacZ base that contains published information about protein. The software runs only on IBMcompatible DNA sequence alterations on over 100 mutants. machines running Microsoft Windows. The soft-Information on the literature citation, mutagenic ware and lacZ database are freely available via conditions, organs from specific animals, mutation the Internet (http://sunsite.unc.edu/dnam/mainpafrequency in each organ, specific mutation, amino ge.html). acid change, and other data are provided for each These programs simplify the analysis of the r a p mutant.

idly increasing information about lacZ mutation. We have also produced a software package for The programs permit the facile comparison between the analysis of the lacZ database. Routines have different lacZ data sets as well as the identification been developed for the analysis of single base s u b of mutational patterns that may be of importance to stitutions, including programs to 1) determine experimenters studying the mechanisms of mutation whether two mutational spectra are statistically difand mutational spectra in transgenic animals. ferent, 2) determine whether mutations show a DNA o 1996 Wiley-Liss, Inc.

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