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Damage to the nigrostriatal system in the MPTP-treated SAMP8 mouse

โœ Scribed by Jing Liu; Yan-Yong Wang; Li Liu; Quan-Dong Wang; Zhen-Yun Yuan; Zhong-Xia Zhang; Ping Gu; Ming-Wei Wang


Book ID
116770958
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
698 KB
Volume
448
Category
Article
ISSN
0304-3940

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Acute ultrastructural effects of MPTP on
โœ Jeffrey A. Cochiolo; Reza Ehsanian; David K. Bruck ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 741 KB

Acute doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) elicited degenerative and apparently compensatory changes in the nigrostriatum of injected animals within 1 day of treatment. In the substantia nigra pars compacta (SNc), low-dose (20 mg/kg) administration elicited early degeneration