Dopamine receptor plasticity following MPTP-induced nigrostriatal lesions in the mouse
β Scribed by Frederic B. Weihmuller; John P. Bruno; Norton H. Neff; Maria Hadjiconstantinou
- Book ID
- 118323241
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 255 KB
- Volume
- 180
- Category
- Article
- ISSN
- 0014-2999
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Acute doses of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) elicited degenerative and apparently compensatory changes in the nigrostriatum of injected animals within 1 day of treatment. In the substantia nigra pars compacta (SNc), low-dose (20 mg/kg) administration elicited early degeneration