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``DAKLI'': A Multipurpose Ligand with High Affinity and Selectivity for Dynorphin (κ Opioid) Binding Sites

✍ Scribed by Avram Goldstein, John J. Nestor, Asha Naidu and Sherry R. Newman


Book ID
123635848
Publisher
National Academy of Sciences
Year
1988
Tongue
English
Weight
975 KB
Volume
85
Category
Article
ISSN
0027-8424

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The synthesis, receptor binding, and preliminary structural characterisation of trishomocubanes of types pentacyclo [5.4.0.02'6.03'l°.05'9]undecylamines and 4-azahexacyclo[5.4.1.0E'6.03'l°.05'9.08'll]dodecanes are described. These ligands demonstrated high selectivity and affinity for the sigma bind