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DA agonists - Non-Ergot derivaties: Piribedil

Book ID
102506020
Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
54 KB
Volume
17
Category
Article
ISSN
0885-3185

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โœฆ Synopsis

Piribedil is a non-ergot derivative D2/D-3 agonist 1 with alpha-2 antagonistic effects 2 . Piribedil is effective in reversing parkinsonian symptoms in the MPTP-treated primate 3 . The clinical effects of piribedil cause lower prolactin plasma levels and blood pressure, and induces nausea. There is also some evidence that piribedil has neuroprotective effects in experimental models 4 .

PHARMACOKINETICS

Piribedil is administered orally, Tmax is reached within 1 hour, and it has a relatively long plasma elimination half-life (20 hours). Piribedil solubility allows it to be used intravenously for experimental purposes or acute challenge tests.

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