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D1- and D2-dopamine receptor occupancy during treatment with conventional and atypical neuroleptics

✍ Scribed by L. Farde; F. A. Wiesel; A. L. Nordström; G. Sedvall

Publisher
Springer
Year
1989
Tongue
English
Weight
616 KB
Volume
99
Category
Article
ISSN
0033-3158

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✍ Dr Paolo Calabresi; Marco De Murtas; Nicola Biagio Mercuri; Giorgio Bernardi 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 807 KB

## Abstract We studied the in vitro electrical activity of rat neostriatal neurons following chronic neuroleptic treatment. In haloperidol‐treated rats, unlike naive animals, activation of neostriatal D2 dopamine receptors induced a potent presynaptic inhibition of glutamate‐mediated excitatory syn