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Occupancy of dopamine D2receptors by the atypical antipsychotic drugs risperidone and olanzapine: theoretical implications

✍ Scribed by W. G. Frankle; R. Gil; E. Hackett; O. Mawlawi; Y. Zea-Ponce; Z. Zhu; L. D. Kochan; C. Cangiano; M. Slifstein; J. M. Gorman; M. Laruelle; A. Abi-Dargham


Publisher
Springer
Year
2003
Tongue
English
Weight
167 KB
Volume
-1
Category
Article
ISSN
0033-3158

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The purpose of the present study was to assess the role of dopamine D 1 and D 2 receptors in the discriminative stimulus properties of the atypical antipsychotic clozapine (CLZ). Two groups of rats were trained to discriminate either a moderate dose of clozapine (5.0 mg/kg) from vehicle or a high do