d-Penicillamin

✍ Scribed by Edgar Lodemann

• Publisher: Springer
• Year: 1979
• Tongue: English
• Weight: 555 KB
• Volume: 66
• Category: Article
• ISSN: 0028-1042
• DOI: 10.1007/bf00399003

✦ Synopsis

D-Penicillamine is used against a variety of diseases. For many years it has been successful in treating Wilson's disease, cystinuria and heavy-metal poisonings. It also proved to be effective against rheumatoid arthritis, scleroderma~ chronic active hepatitis, pulmonary fibrosis and multiple sclerosis. However, the use of D-penicillamine is still limited owing to the frequent occurrence of considerable, though generally reversible, side effects. This article deals with the history of D-penicillamine as well as the methods of its synthesis, its pharmacokinetics, effects and side effects. In addition, the significance of the stereo isomeric L-penicillamine is discussed.

36 Jahre D-Penicillamin

Als 1943 Abraham et al. [1] bei der Konstitutionsaufklfirung der Penicilline ein allen Penicillinen gemeinsames Spaltprodukt als fl,fl-Dimethyl-D-cystein (Fig. 1) identifizieren konnten, war noch nicht abzusehen, dab diese D-Penicillamin genannte Verbindung Jahre sp/iter zu groBer medizinischer Bedeutung kommen sollte. Zun/ichst erweckte diese D-Aminos/iure vor allem das Interesse der Biochemiker am L-Isomer, der den na-S N SH NH2