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(D-MET2, PRO5)-enkephalinamide: a potent morphine-like analgesic

✍ Scribed by J.I. Székely; A.Z. Rónai; Zsuzsa Dunai-Kovács; Erzsébet Miglécz; Ilona Berzétri; S. Bajusz; L. Gráf

Book ID: 118322298
Publisher: Elsevier Science
Year: 1977
Tongue: English
Weight: 145 KB
Volume: 43
Category: Article
ISSN: 0014-2999
DOI: 10.1016/0014-2999(77)90032-2

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The tolerance-development capacities of beta-endorphin, [D-Met2, Pro5]-enkephalinamide, and morphine were compared in rats, and the dependence capacity of morphine was compared with that of the enkephalin analogue in mice. Tolerance to the analgesic effect, as measured by the tail-flick test, develo