d-6-Deoxy-myo-inositol 1,3,4,5-tetrakisphosphate, a mimic of d-myo-inositol 1,3,4,5-tetrakisphosphate: biological activity and pH-dependent conformational properties
β Scribed by Graeme Horne; Clarisse Maechling; Andrea Fleig; Masato Hirata; Reinhold Penner; Bernard Spiess; Barry V.L. Potter
- Book ID
- 116288807
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 424 KB
- Volume
- 320
- Category
- Article
- ISSN
- 0006-291X
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π SIMILAR VOLUMES
In the paper by G. Horne and B. V. L. Potter published in Chem. Eur. J. 2001, 7, 80, there is a mistake in the drawing of some regiochemistry of the structural diagrams in Schemes 1 Β± 3. The correct structures are given below.
Chemical synthesis of D-myo-inositol 1,3,4,5\_tetrakisphosphate was accomplished starting from myo-inositol.
The synthesis of 6-deoxy-D-myo-inositol-l,3,4,5-tetrakisphosphates is described. The access to opticaly pure Ins(l,3,4,5)P4 analogues was carried out from deoxy myo inositol precursors derived from D-galactose. Modification of Ins(1,3,4,5)P4 analogues by lipophilie substituents has been investigated