𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Cα-Tetrasubstituted amino acid based peptides in asymmetric catalysis

✍ Scribed by Giulia Licini; Marcella Bonchio; Quirinus B. Broxterman; Bernard Kaptein; Alessandro Moretto; Claudio Toniolo; Paolo Scrimin

Publisher
Wiley (John Wiley & Sons)
Year
2006
Tongue
English
Weight
245 KB
Volume
84
Category
Article
ISSN
0006-3525

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

C^α^‐tetrasubstituted α‐amino acids constitute a powerful tool for controlling the conformation of short peptide sequences. Chiral peptides may be used in stereoselective reactions both for asymmetric induction and in kinetic resolution. By reviewing recent data from our own laboratories and by presenting new results on the stereoselective oxidation of chalcone to the corresponding oxide, this contribution shows that the control of peptide conformation is a critical issue in order to achieve successful stereoselective catalysis. © 2005 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 84: 97–104, 2006

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at [email protected]

📜 SIMILAR VOLUMES

Turn stabilization in short peptides by
Turn stabilization in short peptides by Cα-methylated α-amino acids
✍ Marco Crisma; Alessandro Moretto; Marta De Zotti; Fernando Formaggio; Bernard Ka 📂 Article 📅 2005 🏛 Wiley (John Wiley & Sons) 🌐 English ⚖ 418 KB

## Abstract The crystal‐state conformations of three protected tripeptides, four tetrapeptides, and one pentapeptide, heavily based on the chiral C^α^‐methylated α‐amino acids Iva, (αMe)Nva, and (Me)Val, were assessed by X‐ray diffraction analyses. The eight peptide sequences are as follows: Z(DI