Cytotoxicity of modified indole alkaloids

✍ Scribed by David G. I. Kingston; S. M. Sami

• Publisher: John Wiley and Sons
• Year: 1979
• Tongue: English
• Weight: 340 KB
• Volume: 68
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600681117

✦ Synopsis

Indole alkaloids of the iboga series were structurally modified by incorporation of a 3,4-dimethoxybenzyl or -benzoyl unit so that they contained the N-O-O triangle required for antileukemic activity according to the triangulation hypothesis. The cytotoxicities of the modified alkaloids in the in vitro P-388 system were not significantly increased over the unmodified alkaloids, suggesting that the triangulation hypothesis does not apply in this series at least.