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Cytotoxicity of Benzo[c]phenanthridinium Alkaloids in Isolated Rat Hepatocytes

✍ Scribed by Jitka Ulrichová; Daniela Walterová; Ctirada Vavrečková; Vojtěch Kamarád; Vilím Šimánek

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
396 KB
Volume
10
Category
Article
ISSN
0951-418X

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✦ Synopsis

Sanguinarine, chelerythrine and fagaronine were examined for hepatotoxic effect. Administration of sanguinarine and chelerythrine (10mglkglday; i.p.) produced marked parenchymal injury not found in the livers of fagaronine treated rats. In chronic administration of sanguinarine (0.2 mgFgl56 days; i.p.) degeneration and necrosis were not observed in the liver. The effect of the alkaloids was tested by enzyme leakage (LDH and ASAT) and changes in glutathione levels in isolated rat hepatocytes. Sanguinarine produced the greatest toxicity followed by lesser toxicity in the case of chelerythrine while no toxicity was displayed with fagaronine. These effects correlate with pK,. values for pseudobase formation. Finally, no increased lipid peroxidation or mitochondria1 membrane damage were found.

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