Characterization of the transport of a synthetic bile salt, iodinated cholyl-glycyl-tyrosine, in isolated cultured rat hepatocytes
✍ Scribed by John C. Deutsch; Mieko M. Iwahashi; Eileen M. Sutherland; John Mapoles; Francis R. Simon
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 723 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0270-9139
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✦ Synopsis
taken up primarily through a sodium-dependent transport system (1-3). Organic anions such as indocyanine green, along with unconjugated bile salts, appear to be taken up by a separate sodium-independent transporter (2, 4, 5). The two carriers have been tentatively identified as a 48-kD protein for sodiumdependent uptake and a 54-kD protein for sodiumindependent uptake (6-8). Others, however, have proposed that many proteins are involved (9).
Recently a high-specific-activity, iodinated, hydroxylated, conjugated bile salt -lZ5I-labeled cholyl-glycyl-