✦ LIBER ✦

Cytotoxic T lymphocyte-mediated lysis via the Fc receptor of target cells

✍ Scribed by Uwe D. Staerz; Michael J. Bevan

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 691 KB
Volume: 15
Category: Article
ISSN: 0014-2980
DOI: 10.1002/eji.1830151206

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✦ Synopsis

Cytotoxic T lymphocyte-mediated lysis via the Fc receptor of target cells*

The murine monoclonal antibody F23.1 reacts with an allotypic determinant on the T cell receptors of about 25% of peripheral T lymphocytes in most common mouse strains. In this report we demonstrate that this IgG2, antibody bound to the receptor of a cytotoxic effector T cell can direct that cell to lyse any target cell which expresses receptors for IgG2,. Thus, allotype-positive, Lyt-2' T lymphocytes from either concanavalin Aor F23.1-activated cell cultures are recruited as cytotoxic effector cells which lyse targets via the Fc receptor. Concanavalin A-induced T cell blasts depleted of Lyt-2' cells do not mediate cytotoxic effects in this system. The data presented here confirm earlier observations that monoclonal anti-T cell receptor antibodies attached to the surface of a cell can act as target structures for T cell-mediated lysis.

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