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The LFA-1/ICAM cell adhesion pathway is involved in tumor-cell lysis mediated by bispecific monoclonal-antibody-targeted T lymphocytes

✍ Scribed by Silvano Ferrini; Sabrina Sforzini; Anna Cambiaggi; Alessandro Poggi; Raffaella Meazza; Silvana Canevari; Maria Ines Colnaghi; Lorenzo Moretta

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
752 KB
Volume
56
Category
Article
ISSN
0020-7136

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✦ Synopsis

We investigated the role of the LFA-I /ICAM, VLA-4/VCAM-I and CD2/LFAJ adhesion pathways in the cytolysis of tumor cells mediated by an anti-EGF-R/anti-CD3 bispecific monoclonal antibody (biMAb). The biMAb induced efficient lysis of

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## Abstract The cure of human Hodgkin's tumors heterotransplanted into SCID mice can be achieved by two bispecific monoclonal antibodies (Bi‐mAb) directed against the tumor‐associated CD30 antigen and CD3 and CD28, respectively, and normal peripheral human blood T cells. We investigated the role of