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Cytotoxic T lymphocyte (CTL)-mediated cytolysis proceeds in the absence of Na+H+ antiport activity: Regulation of cytosolic pH by the Na+H+ antiport in a cloned CTL

✍ Scribed by T.Kevin Howcroft; Leslie M. Loew; Edward J. Cragoe Jr.; Richard R. Lindquist


Book ID
113134810
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
907 KB
Volume
135
Category
Article
ISSN
0008-8749

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To explore further the mechanisms that regulate the Na+/H + antiport in human platelets, we examined the effect of Na + pump inhibition by ouabain and K + removal from the extracellular medium on parameters of this transport system. Treatment with ouabain resulted in increased cytosolic free Ca 2+ a