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Cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism confers susceptibility to thyroid associated orbitopathy

✍ Scribed by Bijayeswar Vaidya; Helen Imrie; Petros Perros; Jane Dickinson; Mark I McCarthy; Pat Kendall-Taylor; Simon HS Pearce

Book ID
117312572
Publisher
The Lancet
Year
1999
Tongue
English
Weight
49 KB
Volume
354
Category
Article
ISSN
0140-6736

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Cytotoxic T lymphocyte antigen-4 (CTLA-4
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✍ Kosh Agarwal; Albert J. Czaja; David E. Jones; Peter T. Donaldson πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 78 KB

Genetic susceptibility to type 1 autoimmune hepatitis is indicated by a preponderance of female subjects and strong associations with human leukocyte antigens (HLA) DRB1\*0301 and DRB1\*0401. The gene encoding cytotoxic T-lymphocyte antigen-4 (CTLA-4) on chromosome 2q33 may also influence autoimmuni