β Scribed by Nigel B. Perry; John W. Blunt; Murray H.G. Munro
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A, B and C have been isolated as the major cytotoxic pigments of three different L.atruncufia spot@ species from New Zealand.. The lH-and laC!-I&R spectra of ihe mious%y reported discorhabdin C 1 have been assigned. The strracture6 of discorhabdins A 2 and B 3 have been established by spe+a.l comparisons (especiaIly NMR) 'with 1. The discorhabdins are strongly cytotoxic (P388 EDsa's 0.03-0.1 pg/ml) and antimicrobial.
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Two cytotoxic alkaloids, haliclamines A and B, have been isolated from a sponge Haliclona sp., and their structures were elucidated mainly by spectroscopic analyses including extensive 2D NMR experiments.
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Two new callipeltin-related acyclic peptides (2 and 3) have been isolated, together with callipeltins A-C from the marine sponge Latrunculia sp. collected at the Vanuatu Islands. The gross structures of new compounds were elucidated by spectroscopic data. The application of the Marfey's analysis on