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Cytotoxic mechanisms in different forms of T-cell-mediated drug allergies

โœ Scribed by P. C. Kuechler; M. Britschgi; S. Schmid; Y. Hari; B. Grabscheid; W. J. Pichler

Book ID
110885320
Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
546 KB
Volume
59
Category
Article
ISSN
0105-4538

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Cellular mechanisms of T cell mediated d
Cellular mechanisms of T cell mediated drug hypersensitivity
โœ Basil O Gerber; Werner J Pichler ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 135 KB

Noncovalent drug presentation leads to the activation of drug-specific T cells. In some patients with hypersensitivity, such a response occurs within hours even upon the first exposure to the drug. Thus, the reaction to the drug might not be due to a classical, primary response, but rather mediated