Cellular mechanisms of T cell mediated drug hypersensitivity

✍ Scribed by Basil O Gerber; Werner J Pichler

• Publisher: Elsevier Science
• Year: 2004
• Tongue: English
• Weight: 135 KB
• Volume: 16
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/j.coi.2004.09.016

✦ Synopsis

Noncovalent drug presentation leads to the activation of drug-specific T cells. In some patients with hypersensitivity, such a response occurs within hours even upon the first exposure to the drug. Thus, the reaction to the drug might not be due to a classical, primary response, but rather mediated by existing, preactivated T cells that are cross specific for the drug, and have an additional (peptide) specificity as well.