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Cytotoxic effects of intra and extracellular zinc chelation on human breast cancer cells

✍ Scribed by Mohammad Hashemi; Saeid Ghavami; Mehdi Eshraghi; Evan P. Booy; Marek Los


Book ID
113586603
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
893 KB
Volume
557
Category
Article
ISSN
0014-2999

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Cytotoxic and DNA synthesis inhibitory effects of several iron chelators with different physicochemical properties have been tested in four myeloid leukaemic cell lines (U937, K562, ML2 and HL60). The small lipophilic chelators 8-hydroxyquinoline, tropolone an5d omadine at 2 x lo-%, caused substanti