✦ LIBER ✦

Cytotoxic and DNA-inhibitory effects of iron chelators on human leukaemic cell lines

✍ Scribed by George J. Kontoghiorghes; Andrea Piga; A. Victor Hoffbrand

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 613 KB
Volume: 4
Category: Article
ISSN: 0278-0232
DOI: 10.1002/hon.2900040303

No coin nor oath required. For personal study only.

✦ Synopsis

Cytotoxic and DNA synthesis inhibitory effects of several iron chelators with different physicochemical properties have been tested in four myeloid leukaemic cell lines (U937, K562, ML2 and HL60). The small lipophilic chelators 8-hydroxyquinoline, tropolone an5d omadine at 2 x lo-%, caused substantial inhibition of labelled leucine and thymidine uptake into cells and also cell death following 4-h incubation. These effects were approximately 10-fold increased when the drugs were pre-incubated with equimolar amounts of iron. Iron alone and hydrophilic chelators e.g. desferrioxamine had insignificant cytotoxic and DNA synthesis inhibitory effects under the same conditions.

📜 SIMILAR VOLUMES

Cytotoxic Effects of Quinoxaline Derivat

Cytotoxic Effects of Quinoxaline Derivatives on Human Cancer Cell Lines

✍ Hee-Won Yoo; Yun-Sil Lee; Myung Eun Suh; Dong Jin Kim; Sang Woo Park 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 36 KB 👁 2 views

ChemInform Abstract: Cytotoxic Effects o

ChemInform Abstract: Cytotoxic Effects of Quinoxaline Derivatives on Human Cancer Cell Lines.

✍ H.-W. YOO; Y.-S. LEE; M. E. SUH; D. J. KIM; S. W. PARK 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 27 KB

Effect of iron chelators on proliferatio

Effect of iron chelators on proliferation and iron uptake in hepatoma cells

✍ Anthony Kicic; Anita C. G. Chua; Erica Baker 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 382 KB 👁 2 views

## BACKGROUND. The siderophore desferrioxamine mesylate (DFO) is used routinely in clinical practice to treat diseases of iron (Fe) overload. Recent studies suggest that DFO and other chelators may have potential in the treatment of cancer. The current study reports the findings obtained when a nu

Growth-inhibitory effects of combination

Growth-inhibitory effects of combination chemotherapy for human pancreatic cancer cell lines

✍ Seiki Matsuno; Hirotake Hisano; Masao Kobari; Satoshi Akaishi 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 533 KB

Inhibitory effect of pisosterol on human

Inhibitory effect of pisosterol on human glioblastoma cell lines with C-MYC amplification

✍ Edmundo L. R. Pereira; Patrícia D. L. Lima; André S. Khayat; Marcelo O. Bahia; F 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 392 KB 👁 1 views

## Abstract Despite the remarkable progress in the characterization of the molecular pathogenesis of glioblastoma multiforme (GBM), these tumors remain incurable and, in most cases, refractory to aggressive cytotoxic treatments. We conducted a morphological and cytogenetic study in two GBM cell lin

Inhibitory effect of cholera toxin on hu

Inhibitory effect of cholera toxin on human natural cell-mediated cytotoxicity and its augmentation by interferon

✍ Akira Fuse; Takeyuki Sato; Tsuguo Kuwata 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 French ⚖ 672 KB

## Abstract Cholera toxin inhibits human natural cell‐mediated cytotoxicity in a dose‐ and time‐dependent manner. Pretreatment of lymphocytes with 10 ng/ml of cholera toxin for 2 h almost completely inhibited cytolysis. Interferon augmented human natural cell‐mediated cytolysis, but when lymphocyte