The fragile histidine triad (FHIT) tumor suppressor gene at 3p14.2 has abnormalities in several types of human cancers. To investigate the potential role of FHIT in cervical cancer, which exhibits frequent loss of heterozygosity of 3p, we have examined primary cervical cancer samples from 28 patient
Cytotoxic blocking activity in invasive squamous cell carcinoma of the human uterine cervix
โ Scribed by Morteza M. Dini; Dr. Isidoro Faiferman
- Publisher
- John Wiley and Sons
- Year
- 1980
- Tongue
- English
- Weight
- 348 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0008-543X
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โฆ Synopsis
A cell-mediated cytotoxicity assay was used to evaluate the specific reactivity of patients with squamous cell carcinoma to an established cell line derived from squamous cell carcinoma of the cervix. Heat inactivated sera from patients with squamous cell carcinoma could very effectively nullify this specific cytotoxicity (P < 0.01). There was no significant difference between the cytotoxic blocking activity of the sera from patients with different stages of the cancer in this experimental setup.
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