Cytotoxic activity of the adenine arabinoside analogs, 2′-azido- and 2′-amino-2′-deoxy-β-D-arabinofuranosyladenine
✍ Scribed by Sang He Lee; Frank M. Unger; Rudolf Christian; Alan C. Sartorelli
- Book ID
- 115774602
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- English
- Weight
- 263 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0006-2952
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## Abstract The anticancer effects of 9‐β‐(2′‐azido‐2′‐deoxy‐D‐arabinofuranosyl)adenine (arazide) were compared to those of 9‐β‐D‐arabinofuranosyladenine (araA) in P388 leukemia cells. Arazide was less susceptible than araA to deamination by a partially purified preparation of adenosine deaminase f
Considerable effort has been devoted over the years to the synthesis of amino nucleosides spurred on largely by the antibiotic properties exhibited by many of them. l-4 However, the synthesis of 2'-amino-2'-deoxy nucleosides which have the amino group in the "up" (arabino) configuration has proved r