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Cytostatic activity against HeLa cells of a series of indazole and indole derivatives; synthesis and evaluation of some analogues

✍ Scribed by Arán, Vicente J. ;Flores, María ;Muñoz, Pilar ;Ruiz, José R. ;Sánchez-Verdú, Prado ;Stud, Manfred

Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
803 KB
Volume
1995
Category
Article
ISSN
0947-3440

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✦ Synopsis

The remarkable cytostatic activity of 1-substituted indazolols 2a, b, condensed indazolinones 4a-c and indoxyl derivatives 5a, b against HeLa cells is reported. Three different approaches to the synthesis of indazolophthalazinone 4a, representing alternatives to those previously reported, were studied. Several compounds related to the mentioned indazolols and indazohnones were obtained and their cytostatic activity against HeLa cells was tested. Among them we can menhon the tetracyclic SO2 analogue 14 and the condensed pyridine derivative 18, the tricyclic pyrazolophthalazinone 22 and the bicyclic pyrazolodiazepinone 25, which were prepared by taking advantage of the reactivity of heterocyclic spiro aminimides.

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