Cytosine methylation and the fate of CpG dinucleotides in vertebrate genomes
β Scribed by David N. Cooper; Michael Krawczak
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 996 KB
- Volume
- 83
- Category
- Article
- ISSN
- 0340-6717
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## Abstract It is demonstrated that a heterologous (chicken) CpG island containing five Sp1 canonical recognition sequences becomes highly methylated in the genome of transgenic mice bearing one or several copies of the transgene. Similar levels of methylation of the chicken CpG island were observe