Cytoplasmic mislocalization of BRCA1 caused by cancer-associated mutations in the BRCT domain
✍ Scribed by José Antonio Rodriguez; Wendy W.Y. Au; Beric R. Henderson
- Book ID
- 116980848
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 920 KB
- Volume
- 293
- Category
- Article
- ISSN
- 0014-4827
No coin nor oath required. For personal study only.
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## Abstract BARD1 (BRCA1‐associated RING domain) was identified by yeast two‐hybrid screening as a protein interacting with BRCA1. Somatic and germline mutations of __BARD1__ have been detected in sporadic breast, ovarian, and endometrial cancers. The present study represents the first description
ABD mutations demonstrated that with only one exception disease-associated substitutions, surrounding hinge 1 demonstrated no tendency to form actin-filamin foci. The exception, a substitution in filamin repeat 6, lies within a region previously implicated in filamin-actin binding. These data are co