A somatic mutation in the 5′UTR of BRCA1 gene in sporadic breast cancer causes down-modulation of translation efficiency
✍ Scribed by Signori, Emanuela; Bagni, Claudia; Papa, Sara; Primerano, Beatrice; Rinaldi, Monica; Amaldi, Francesco; Fazio, Vito Michele
- Book ID
- 110064880
- Publisher
- Nature Publishing Group
- Year
- 2001
- Tongue
- English
- Weight
- 157 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0950-9232
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## Abstract Breast cancer occurs rarely in men and risk factors for the disease include germline mutations of the __BRCA2__ gene. High frequency of allelic loss at the __BRCA2__ locus has been reported in sporadic breast tumors, but somatic mutations of __BRCA2__ are very rare. Here we report the f
The cloning of the breast and ovarian cancer susceptibility gene, BRCA1, allows direct estimation of the proportion of these cancers in the general population which can be attributed to germline mutations in this gene. We have used a combination of SSCP, heteroduplex analysis, and chemical cleavage