Cytoplasmic islet cell antibodies remain valuable in defining risk of progression to type 1 diabetes in subjects with other islet autoantibodies
β Scribed by Massimo Pietropaolo; Shui Yu; Ingrid M. Libman; Susan L. Pietropaolo; Karen Riley; Ronald E. LaPorte; Allan L. Drash; Sati Mazumdar; Massimo Trucco; Dorothy J. Becker
- Book ID
- 110905324
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 112 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1399-543X
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π SIMILAR VOLUMES
Forty-four children with Type 1 (insulin-dependent) diabetes (aged 0.7-16.7 years) were observed from diagnosis for cytoplasmic islet cell antibodies and serum C-peptide concentrations. Islet cell antibodies were analysed by indirect immunofluorescence for both conventional IgG and complement-fixing
Genetic determination as well as prospective analysis of islet cell autoantibodies and autoantibodies to insulin were conducted in a population of 479 first degree relatives of 174 Type 1 (insulin-dependent) diabetic patients. Analysis of HLA haplotypes within families illustrated the high frequency