✦ LIBER ✦

Cytophotometric analysis of lytically and persistently infected tissue culture cells with measles virus

✍ Scribed by H. Harms; H. M. Aus; V. ter Meulen

Publisher: John Wiley and Sons
Year: 1981
Tongue: English
Weight: 686 KB
Volume: 1
Category: Article
ISSN: 0196-4763
DOI: 10.1002/cyto.990010509

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Lytically and persistently infected VERO and LUB cells were cytophotometrically characterized with the aid of computer analysis. Images scanned at 260 and 280 nm were processed by computer algorithms. With this approach, infected cells could be segmented and differentiated from uninfected cells. Lytically and persistently infected cells could be distinguished by distinct differences in nuclear and cytoplasmic optical densities. These findings are supported by biologic data based on the analysis of virus‐specific proteins and nucleic acids. The applied computer aided cytophotometry provides a new approach in the study of virus‐cell interaction.

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