✦ LIBER ✦
Effect of prostaglandin A1 in porcine cells persistently infected with classical swine fever virus
✍ Scribed by Tânia Rosária Pereira Freitas; Lúcio Ayres Caldas; Moacyr Alcoforado Rebello
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- English
- Weight
- 177 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0233-111X
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✦ Synopsis
Abstract
Cyclopentenone prostaglandins are potent inhibitors of a wide variety of RNA and DNA viruses. In this report we describe that prostaglandin A~1~ (PGA~1~) potently inhibited the replication of classical swine fever virus in cultures of PK‐15 cells. The highest non‐toxic dose (5 μg/ml) inhibited virus yield in 99% at the initial phase of infection and in 77% in persistent infected cells. However when PGA~1~ was removed from persistently infected cells, the inhibition of virus replication was partially reverted.