Cytomorphological correlates of epidermal growth factor receptor mutations in lung carcinoma
β Scribed by Elena F. Brachtel; A. John Iafrate; Eugene J. Mark; Vikram Deshpande
- Book ID
- 111660184
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 234 KB
- Volume
- 35
- Category
- Article
- ISSN
- 8755-1039
- DOI
- 10.1002/dc.20617
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## Abstract Recent studies have indicated that somatic mutations in the epidermal growth factor receptor (EGFR) gene have been identified in a subset of patients with nonsmallβcell lung cancer (NSCLC) and are associated with sensitivity to the EGFRβtyrosineβkinase inhibitors. These mutations have b
Somatic mutations in the tyrosine kinase (TK) domain of the epidermal growth factor receptor (EGFR) gene in lung cancers have generated enormous interest, because they predict for sensitivity to TK inhibitors (TKIs). While mutational status is of great importance in determining response to TKIs, it