𝔖 Bobbio Scriptorium
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Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

✍ Scribed by Lowin, Bente; Hahne, Michael; Mattmann, Chantal; Tschopp, Jürg


Book ID
109789524
Publisher
Nature Publishing Group
Year
1994
Tongue
English
Weight
356 KB
Volume
370
Category
Article
ISSN
0028-0836

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✍ Karim Benihoud; Danielle Bonardelle; Pierre Bobé; Nicole Kiger 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 701 KB

Autoimmune-prone MRL/lpr mice, homozygous for the lpr mutation, exhibit defective apoptosis and develop generalized lymphoproliferation with the accumulation of a double-negative (DN: CD4- CD8-) T cell population. The capacity of lpr T lymphocytes to effectuate Fas- and perforin-mediated cytotoxicit