## Immunosuppressive treatments in Crohn's disease induce myelodysplasia and leukaemia To the editor: We report on a pediatric and an adult patient suffering from Crohn's disease (CD), treated with mercaptopurine (6-MP) and anti-TNF-a therapy, who respectively subsequently developed MDS with monos
Cytologic features of post-transplant lymphoproliferative disorder
โ Scribed by David Dusenbery; Michael A. Nalesnik; Joseph Locker; Steven H. Swerdlow
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 342 KB
- Volume
- 16
- Category
- Article
- ISSN
- 8755-1039
No coin nor oath required. For personal study only.
โฆ Synopsis
The cytology files of the University of Pittsburgh Medical Center were searched from 1990 to present for cases diagnosed as or suspicious for PTLD. Fourteen specimens from 12 patients were identified. Five specimens were eliminated from consideration, three because of lack of histologic confirmation and two because only histologic core biopsy material was available for review. The remaining nine specimens (two FNAs, one from lung and one from peripancreatic lymph node; three pleural fluids; two peritoneal fluids; one cerebrospinal fluid; and one gastric brushing) were retrospectively reviewed.
๐ SIMILAR VOLUMES
The tumorigenic potential of six post-transplant B-cell lymphoproliferative disease (PTLD) lesions was evaluated in SCID mice. Three animals developed local subcutaneous B cell tumours, two of which contained Epstein-Barr virus (EBV) DNA. Two animals developed CD3 positive thymic neoplasms, and one