Farnesyltransferase Inhibitors Inhibit t
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Jochen Wiesner; Katja Kettler; Jacek Sakowski; Regina Ortmann; Alejandro M. Katz
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Article
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2004
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John Wiley and Sons
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English
โ 127 KB
๐ 1 views
Farnesyltransferase catalyzes the posttranslational modification of numerous proteins involved in intracellular signal transduction by transferring the farnesyl residue of farnesyl pyrophosphate to the thiol of a cysteine side chain of the protein substrate. The cysteine residue belongs to a charact