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Cytokines in the differentiation of Th1/Th2 CD4+ subsets in leishmaniasis

✍ Scribed by Steven L. Reiner; Richard M. Locksley

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 526 KB
Volume: 53
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.240530409

No coin nor oath required. For personal study only.

✦ Synopsis

Leishmania major infect only macrophages in the host, where they reside in endolysosomal compartments into which MHC class II molecules co-localize. Experimental infection in mice has provided a useful model for the differentiation of T h l CD4+ effector lymphocytes that are required for the generation of IFN-y that activates the macrophage to a microbicidal state. Genetically susceptible BALB/c mice aberrantly activate Th2 CD4+ effector cells that are ineffective in arresting infection. Increasing evidence suggests that, rather than discrete parasite antigens or MHC molecules, cytokines mediate the critical decision in the developmental switch to either the Thl or Th2 effector phenotype. .

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