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Defective Th1 and Th2 cytokine synthesis in the T-T cell presentation model for lack of CD40/CD40 ligand interaction

✍ Scribed by Lucrezia De Vita; Daniele Accapezzato; Giorgio Mangino; Stefania Morrone; Isabella Santilio; Marco Antonio Casciaro; Danila Fava; Guglielmo Bruno; Gianfranco Del Prete; Angela Santoni; Vincenzo Barnaba


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
229 KB
Volume
28
Category
Article
ISSN
0014-2980

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CD40 ligand signals optimize T helper ce
✍ Johanne Poudrier; Dominic van Essen; Susana Morales-Alcelay; Tomas Leanderson; S πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 278 KB πŸ‘ 1 views

The role of CD40 in the development of germinal centers (GC) is not simply to initiate the B cell response, as rudimentary GC can develop in CD40 -/-mice that are injected with CD40immunoglobulin (Ig) fusion protein. This indicates that CD40 ligand (CD40L) transduces a signal to T cells that is impo