CD40 ligand signals optimize T helper ce
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Johanne Poudrier; Dominic van Essen; Susana Morales-Alcelay; Tomas Leanderson; S
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Article
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1998
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John Wiley and Sons
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English
β 278 KB
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The role of CD40 in the development of germinal centers (GC) is not simply to initiate the B cell response, as rudimentary GC can develop in CD40 -/-mice that are injected with CD40immunoglobulin (Ig) fusion protein. This indicates that CD40 ligand (CD40L) transduces a signal to T cells that is impo