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Cytokines and myelin antibodies in Crow-Fukase syndrome

✍ Scribed by Kyoko Saida; Mitsuhiro Ohta; Hideshi Kawakami; Takahiko Saida

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
254 KB
Volume
19
Category
Article
ISSN
0148-639X

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✦ Synopsis

syndrome (CFS) ,z~11~'z~18 or PO-EMS syndrome,' consists of polyneuropathy, organomegaly, endocrinopathy, plasma cell dyscrasia, skin changes, edema, and bone lesions. The increase of interleukin (IL)-lp,326 IL-63,5,6,10 and tumor necrosis factor (TNF)-a4 were reported in the sera of some patients with this syndrome, and the levels of these cytokines correlated to the clinical course of CFS. IL-6 contributes to the final maturation and differentiation of B lymphocytes into plasma cells.' However, it is not known whether these cytokines play important roles in inducing core symptoms such as polyneuropathy and edema in CFS. Most studies are based on a few cases or do not have well-matched disease controls.

In the present study, we measured the levels of these cytokines in sera from patients with CFS as well as rheumatoid arthritis (RA) and progressive systemic sclerosis (PSS) .

Further, to elucidate myelin and axon damages in CFS, we also assayed myelin or axon-related antibodies, including anti-GalCer and GM1, that are present in Guillain-BarrC syndrome," multifocal motor n e ~r o p a t h y , ' ~ and paraproteinemic polyneuropathy.g

Methods

Five patients with the diagnosis of CFS1' and who had proven nerve biopsies were taken into this study.

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Coagulation and vascular abnormalities in Crow-Fukase syndrome
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Coagulation and vascular abnormalities were studied in 4 patients with Crow-Fukase syndrome (CFS or POEMS) to understand the pathophysiology. Fibrinogen, fibrinopeptide A, and thrombin-antithrombin complexes (TAT) increased in sera during active phase of CFS. In nerves of 2 untreated cases, the endo

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Crow-Fukase or POEMS syndrome of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes is a rare multisystem disorder of obscure pathogenesis that is associated with microangiopathy, neovascularization, and accelerated vasopermeability. We examined the levels of the vascular endo