Complement-king antibodies to peripheral nerve myelin (anti-PNM Ab) can be detected in the serum of patients with Guillain-Barre syndrome (GBS). Kinetics of these antibodies can be correlated with the changing clinical course; the appearance of activation products of the terminal complement cascade
Clinical correlation with anti-peripheral-nerve myelin antibodies in Guillain-Barré syndrome
✍ Scribed by Dr Carol L. Koski; Edward Gratz; John Sutherland; Richard F. Mayer
- Publisher
- John Wiley and Sons
- Year
- 1986
- Tongue
- English
- Weight
- 518 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0364-5134
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An earlier investigation from our laboratory (Ilyas AA, Willison HJ, Quarles RH, et al. Serum antibodies to gangliosides in Guillain-Barre syndrome. Ann Neurol 1988;23:440-447) demonstrating the presence of high levels of antiganglioside antibodies in the sera of 5 of 26 patients with Guillain-Barre
We measured the autoantibodies to GM1, central myelin proteins, and cardiolipin in 30 GBS patients using sensitive ELISA and Western blot techniques. The sequential modifications of titers during plasma-exchange (PE) and at follow-up were investigated in 15 patients. In pretreatment sera, we found s