JAK/STAT signaling by cytokine receptors
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Kathleen D Liu; Sarah L Gaffen; Mark A Goldsmith
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Article
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1998
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Elsevier Science
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English
⚖ 712 KB
The JAK/STAT pathway is recognized as one of the major mechanisms by which cytokine receptors transduce intracellular signals. This system is regulated at multiple levels, including JAK activation, nuclear trafficking of STAT factors, and negative feedback loops. Gene deletion studies have implicate