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Cytokine-induced nitric oxide induces mitochondrial dysfunction and cardiac depression in endotoxin-treated rat hearts

✍ Scribed by Kazuko Akashi; Tetsuya Tatsumi; Natsuya Keira; Jun Shiraishi; Satoaki Matoba; Miyuki Kobara; Jun Asayama; Masao Nakagawa

Book ID
119589716
Publisher
Elsevier Science
Year
1998
Tongue
English
Weight
130 KB
Volume
4
Category
Article
ISSN
1532-8414

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## Abstract Because the neurotoxic effects of the antifungal drug amphotericin B (AMB) closely resemble those ascribed to the highly reactive gaseous free radical nitric oxide (NO), we investigated the effect of AMB on NO production in rodent astrocytes. AMB caused a dose‐dependent increase of NO g