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Cytokine and growth factor production by monocytes/macrophages on protein preadsorbed polymers

✍ Scribed by Bonfield, T. L. ;Colton, E. ;Marchant, R. E. ;Anderson, J. M.

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
835 KB
Volume
26
Category
Article
ISSN
0021-9304

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✦ Synopsis

These studies evaluate the effect of biomedical polymers: Biomer, polydimethylsiloxane (PDMS), polyethylene, expanded polytetraf luoroethylene (ePTFE), Dacron, and the control polystyrene with or without adsorbed proteins IgG, fibrinogen, and fibronectin on the ability of activated human monocytes/macrophages to produce Interleukin 1 Beta (IL-1-B), Interleukin 6 (IL-6), and Tumor Necrosis Factor Alpha (TNF-A). Monocytes/macrophages incubated on biomedical polymers with or without protein preadsorption produce variable levels of IL-1-B, IL-6, and TNF-A dependent on the polymer and adsorbed protein. IL-6 was produced in the greatest quantity and was the most influenced by protein adsorption. ePTFE and PDMS polymers were least stimulating while polystyrene was the most stimulating of monocyte activity. Adsorbed IgG consistently altered the ability of the polymers to activate monocytes/macrophages to produce cytokines. These studies provide important insight into conditions which modulate monocyte/macrophage activity in response to protein preadsorbed biomedical polymers.

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