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Cytogenetic effects of promutagens in genetically engineered V79 chinese hamster cells expressing cytochromes P450

✍ Scribed by Kulka, Ulrike; Doehmer, Johannes; Glatt, Hans-Ruedi; Bauchinger, Manfred


Book ID
123381839
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
584 KB
Volume
228
Category
Article
ISSN
0926-6917

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Genetically engineered V79 chinese hamst
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Chinese hamster V79 fibroblasts, frequently used as target cells in short-term tests for mutagenicity, do not possess measurable monooxygenase activity; in particular, enzymatic oxidation of testosterone (T) cannot be demonstrated. If these V79 cells, however, had been transfected with the cDNAencod