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Cytogenetic effects of in vivo administration of methadone and 1-alpha-acetyl methadol (LAAM)

✍ Scribed by S.S. Matsuyama; V. Charuvastra; L.F. Jarvik; T.-K. Fu; K. Sanders; F.-S. Yen


Book ID
119091715
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
69 KB
Volume
38
Category
Article
ISSN
0165-1161

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Methadone is a basic drug highly bound to a1-acid glycoprotein (AGP), a plasma protein that increases in several pathological situations. Our aims were to evaluate the processes (pharmacokinetics-PK and/or pharmacodynamics-PD) associated with changes of methadone analgesia under conditions of increa