## BACKGROUND. Multifocal tumor areas occurred in 12 -22% of patients with renal
Cytogenetic characterization of renal cell carcinoma compared with clinical and histopathological data
β Scribed by K. Junker; A. Schlichter; H. Kosnehl; Ch. Kelbova; D. Katenkamp; U. Claussen; J. Schubert
- Book ID
- 119106365
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 109 KB
- Volume
- 77
- Category
- Article
- ISSN
- 0165-4608
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We report the case of a 26-year-old man with von Hippel-Lindau syndrome (VHL) and two renal cell carcinomas (RCC), one of which was studied cytogenetically. Chromosomal analysis of the RCC showed a translocation that involved chromosomes 3 and 8 with subsequent loss of the derivative chromosome 8. T
## Renal -cell carcinomas (RCC) are clinically, histologically and cytogenetically very heterogeneous. The present histological WHO classification shows no clear correlation between histologic subtypes and specific chromosomal abnormalities. In 1986, a new classification was proposed by Thoenes an