Abnormalities in the p53 gene were studied in a series of cell lines of human squamous-cell carcinoma of the head and neck (SCCHN) and in tumor tissues. Restriction-fragment-length polymorphism (RFLP), quantitative hybridization and immunochemical analysis of mutant p53 proteins were combined to det
โฆ LIBER โฆ
Cytogenetic characterization of head and neck squamous cell carcinoma cell lines as model systems for the functional analyses of tumor-associated genes
โ Scribed by Kolja Freier; Christof Hofele; Karl Knoepfle; Madeleine Gross; Frauke Devens; Gerhard Dyckhoff; Peter Plinkert; Peter Lichter; Christel Herold-Mende
- Book ID
- 111255331
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 293 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0904-2512
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Deletion of 9~21-22 is a common genetic alteration in dysplastic. in situ, and invasive head and neck squamous cell carcinoma (HNSCC). However, a candidate tumor suppressor gene (TSG) at this site has thus far not been identified in HNSCC. We report homozygous deletion of the recently identified mul