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Cytogenetic and molecular studies in the Prader-Willi and Angelman syndromes: An overview

✍ Scribed by Knoll, J. H. M. ;Wagstaff, J. ;Lalande, M.

Publisher: John Wiley and Sons
Year: 1993
Tongue: English
Weight: 526 KB
Volume: 46
Category: Article
ISSN: 0148-7299
DOI: 10.1002/ajmg.1320460103

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✦ Synopsis

Abstract

The majority of patients with Angelman syndrome and Prader‐Willi syndrome have a cytogenetic and molecular deletion of chromosome 15q11q13 with the primary difference being in the parental origin of deletion. Our current understanding of the cytogenetics and molecular genetics of these 2 clinically distinct syndromes will be discussed in this review. © 1993 Wiley‐Liss, Inc.

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