The nature of the cell which gives origin to Hodgkin's disease remains unclear after years of intensive investigation. Cytogenetic data, which are very scarce in Hodgkin's disease, could contribute information which might help elucidate this problem. Review of our own data and others shows that the
Cytogenetic and molecular genetic analysis of abnormal cells in Hodgkin's disease
β Scribed by P.R.K. Koduru; K. Offit; D.A. Filippa; P.H. Lieberman; S.C. Jhanwar
- Book ID
- 119104149
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 514 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0165-4608
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Three Hodgkin's disease-derived cell lines were analysed for the organization of immunoglobulin and T cell receptor genes, for the expression of the interleukin 2 (IL-2) receptor gene, and for the cellular oncogene c-myc. All three cell lines have characteristic genotypic markers of lymphoid cells a
The fusion gene NPM-ALK occurs in a subset of anaplastic large cell lymphomas (ALCLs), as a result of a chromosomal translocation, t(2;5) (p23;q35). It has been suggested that Hodgkin's disease (HD) and ALCL share a common histogenesis because of pathological and phenotypical similarities. In order